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Most of the data on bodybuilders, steroids and testicular atrophy comes from case reports rather than longitudinal or cohort studies, in part because they tend to take so much time to follow up. In an important and somewhat ironic study, Dr. James D. Watson, Ph.D., recently presented his results on this issue in a presentation at the "Steroids, Cortical Layers and Semen," conference in Montreal, Canada. He and his colleagues found that many athletes who had undergone testosterone replacement therapy lost the tissue in their testicles that is related to the volume gained while their levels of testosterone increased. The fact that a large group of steroid users loses tissue in their testicles that is related to testosterone is a problem, Dr. Watson said. "There are some people who are very sensitive to testosterone, like athletes, and that is why some of them might be sensitive and some might be very sensitive to this tissue loss." A few years ago, David H. Semenya, M.D., of the Department of Medicine at the Yale School of Medicine, reported that male testosterone levels in